Type: Interneuron, (sublateral) motor neuron
Connectivity:
- In MoW: SIA
- In WormWiring: SIADLh, SIADRh, SIAVLh, SIAVRh, SIADLm, SIADRm, SIAVLm, SIAVRm
- In Nemanode: SIA
In Wormbase: SIA, SIADL, SIADR, SIAVL, SIAVR
Lineage: AB plpapaapa, AB prpapaapa,
AB plpapappa, AB prpapappa
Location: Ventral ganglion of the head
Description: SIA neurons extend their processes anteriorly into the nerve ring. These processes then exit the nerve ring posteriorly within the ventral or dorsal sublateral cords.
Neurotransmitter/ Neuropeptide:
- Acetylcholine
- PDF-1; pigment dispensing factor homolog (in SIAV)
(Barrios et al., 2012; Loer and Rand, 2022; Duerr et al., 2008; Rand and Nonet, 1997-Appendix 2)
Innexin expression:
- INX-1a
- INX-1b
- INX-2
- INX-7
- INX-10a
- INX-14
- INX-18a
- UNC-7
- UNC-9
(Bhattacharya et al., 2019; Altun et al., 2009)
Receptor expression:
Function:
- In wild type animals the NR is positioned around the center of the isthmus of the pharynx. CWN-2, the C. elegans Wnt5 homolog, and SIA and SIB neurons play an essential role in placement of the NR correctly in this position. CWN-2 is required at the time of nerve ring formation and functions through the Wnt receptor CAM-1. CWN-2 is a ligand for CAM-1 (Ror receptor) and CAM-1 expression in SIA and SIB neurons facilitates this function. When this pathway is perturbed the NR is displaced towards the anterior (Kennerdell et al., 2009).
Reporters
- At CGC:
- Other:
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