PHBL, PHBR

Type: Sensory neuron (chemosensory)
Connectivity:
- In MoW: PHB
- In WormWiring: PHBLh, PHBRh, PHBLm, PHBRm
- In Nemanode: PHB
In Wormbase: PHB, PHBL, PHBR
Lineage: AB plapppappp, AB prapppappp
Location: Right and left lumbar ganglia
Description: Phasmid neurons
Neurotransmitter/Neuropeptide:
- Glutamate
- Serotonin; low likelihood
- NLP-1; neuropeptide-like protein
(Pereira et al., 2015; Nathoo et al., 2001; Sawin et al., 2000; C. Loer, pers. comm.)
Innexin expression:
- CHE-7
- INX-1a
- INX-1b
- INX-7
- INX-10a
- INX-11
- INX-13
- INX-18a
- INX-19 (NSY-5)
- UNC-7
- UNC-9
(Bhattacharya et al., 2019; Schumacher et al., 2012; Altun et al., 2009)

Receptor expression:
- OCR-2; TRPV channel proteins
- OSM-9; TRPV channel protein
- NPR-1; neuropeptide Y receptor like protein
- SRB-6; G protein-coupled serpentine receptor
(Coates and de Bono, 2002; Tobin et al., 2002; Colbert et al., 1997; Troemel et al., 1995)
Function:
- Modulate chemorepulsion behavior in worms (Hilliard et al., 2002)
Reporters:
- At CGC: BL5717 inIs179 [ida-1p::GFP]. GFP is expressed in a subset of neurons and the neuroendocrine uv1 cells of the vulva
- Other:

Click image for closeup view Click pictures for higher resolution images

 
 

Click here for larger version
PHBL (AB plapppappp) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of PHBL (since last PHBL ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB plapppapp); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).
 
 

Click here for larger version
PHBR (AB prapppappp) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of PHBR (since last PHBR ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB prapppapp); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).


Last revision: June 16, 2025
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