DVC

Type: Interneuron
Connectivity:
- In MoW: DVC
- In WormWiring: DVC_h, DVC_m
- In Nemanode: DVC
In Wormbase: DVC
Lineage: C aapaa
Location: Dorsorectal ganglion
Description: Ring interneuron that sends a process from the dorsorectal ganglion along the ventral cord and into the nerve ring.
Neurotransmitter/ Neuropeptide:
- Glutamate
(Serrano-Saiz et al., 2013)

Innexin expression:
- CHE-7
- INX-5
- INX-7
- INX-9
- INX-10
- INX-11
- INX-13
- INX-14
- INX-17 (early larva)
- INX-18
- UNC-7
- UNC-9
(Altun et al., 2009; Bhattacharya et al., 2019)
Receptor expression:
- GLR-1; glutamate receptor subunit
- SER-4; serotonin receptor, variably expressed (the neuron can be DVA instead)
- TRP-4; mechanosensitive TRPN channel
(Tsalik et al., 2003; Hart et al., 1995)
Function:
- It is suggested DVC may be a stretch receptor that functions in backward locomotion. Activation of DVC induces reversal through synapses onto AVA command interneurons and glutamatergic output from DVC is required for this backing (Ardiel and Rankin, 2015).
Reporters:
- At CGC: NC3540 otIs458 [ceh-63p::GFP + unc-119(+)]
- Other:

Click pictures for higher resolution images

Click here for larger version
DVC (C aapaa) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of DVC; dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).

Last revision: May 5, 2025