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DVB
Type: Polymodal (motor neuron, interneuron)
Connectivity:
- In MoW: DVB
- In WormWiring: DVBh, DVBm
- In Nemanode: DVB
In Wormbase: DVB
Lineage: K.p
Location: Dorsorectal ganglion
Description: An excitatory GABAergic motor neuron/interneuron located in dorso-rectal ganglion. Innervates enteric muscles. Born postembryonically from K rectal epithelial cell; during late L1 the K rectal epithelial cell divides to generate DVB (K.p) and K.a which acts as the new rectal epithelial cell. DVB shows experience-dependent morphological plasticity in males with the addition of new neurites (Hart and Hobert, 2018). |
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Neurotransmitter/ Neuropeptide:
- GABA
- Betaine
(McIntire et al., 1993; Wang et al., 2024)
Innexin expression:
- INX-3
- INX-7
- INX-10
- INX-13
- UNC-7
- UNC-9
(Altun et al., 2009)
Receptor expression:
Function:
- Defecation. AVL and DVB are excitatory GABAergic motor neurons for the enteric muscles. Together with AVL, activates expulsion muscle contraction (E.p or EMC) (Avery and Thomas, 1997; McIntire et al., 1993).
- Spicule protraction. In males, optogenetic stimulation of DVB activates the anal depressor muscles, which regulates spicule protraction (LeBoeuf and Garcia, 2016).
Reporters:
- At CGC: OH906 otIs39 [unc-47(delta)::GFP + lin-15(+)]. Also expressed in RMEL/R, AVL, RIS, and PVT.
- Other: |
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Last revision: May 5, 2025 |
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