MUTANT PHENOTYPE-RNAi TERMS

(Courtesy of Wormbase)

Note: Mutant phenotypes as well as gene names that are not included in this list or CGC list can be found in the "tree display" section of each gene in Wormbase. goid= gene ontology ID.

--> List of Gene names at CGC



1. Abs = ABnormal Spindle positioning
Specialization of Spo = abnormal embryonic Spindle Position
and Orientation (was Apo)
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
and
term: mitotic spindle positioning
goid: GO:0018986
definition: The intracellular positioning of the mitotic spindle.
definition_reference: WB:ems
----------------------------------------------------------------------
2. Adl = ADult Lethal
Specialization of Lethal
term: determination of adult life span
goid: GO:0008340
definition: The control of viability and duration in the adult
phase of the life cycle.
definition_reference: WB:ems
and
term: physiological processes
goid: GO:0007582
definition: Those processes specifically pertinent to the
functioning of integrated living units, i.e., cells, tissues,
organs, and organisms.
definition_reference: WB:ems
definition_reference: ISBN:0198506732
----------------------------------------------------------------------
3. Bli = BLIstered
term: cuticular attachment to epithelium (sensu Nematoda)
goid: GO:0040004
definition: Attaching of a cuticle to the epithelium underlying
it, as done in Nematoda.
definition_reference: WB:ems
----------------------------------------------------------------------
4. Bmd = Body Morphology Defect
Specialization of "post-embryonic defect" and "Morphology defect"
term: body morphogenesis (sensu Nematoda)
goid: GO:0040032
definition: Formation and development of organized structures of
the post-embryonic soma.
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
5. Ced = CEll Death abnormality
term: cell death
goid: GO:0008219
definition: The specific activation or halting of processes
within a cell so that its vital functions markedly cease, rather
than simply deteriorating gradually over time, which culminates
in the cell's death.
definition_reference: WB:ems
----------------------------------------------------------------------
6. Clr = CLeaR
Specialization of "post-embryonic defect" and "Morphology defect"
term: osmoregulation
goid: GO:0018987
definition: The control of the osmotic activity of the fluid in a cell,
tissue, organ, or organism.
definition_reference: WB:ems
and
term: negative regulation of FGF receptor signalling pathway
goid: GO:0040037
definition: Negatively controlling or influencing the activity of
the FGF receptor signalling pathway to normal levels.
definition_reference: WB:ems
----------------------------------------------------------------------
7. Con = Constipated
term: defecation
goid: GO:0030421
definition: The expulsion of feces from the rectum.
definition_reference: GO:mah
----------------------------------------------------------------------
8. Cpa = CytoPlasmic Appearance alteration in early embryo
Specialization of Emb
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and of
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
and
term: cytoplasm organization and biogenesis
goid: GO:0007028
definition: Synthesis and ordering of the cytoplasm and its
components.
definition_reference: WB:ems
----------------------------------------------------------------------
9. Cyk = CYtoKinesis defect
Specialization of Emb
term: cytokinesis
goid: GO:0016288
definition: The division of a cell into two daughter cells
following mitosis.
definition_reference: FB:ma
----------------------------------------------------------------------
10. Daf = abnormal DAuer Formation
term: dauer larval development (sensu Nematoda)
goid: GO:0040024
definition: Development of a nematode through the facultative
diapause of the dauer ("enduring") larval stage, with specialized
traits adapted for dispersal and long-term survival, with
elevated stress resistance and without feeding.
definition_reference: WB:ems
definition_reference: ISBN:087969307X
----------------------------------------------------------------------
11. Dpy = DumPY
Specialization of "post-embryonic defect" and "Morphology defect"
term: developmental processes
goid: GO:0007275
definition: Biological processes specifically aimed at the
progression of an organism over time from an initial condition
(e.g., a zygote, or a young adult) to a later condition (e.g., a
multicellular animal or an aged adult).
definition_reference: WB:ems
and
term: morphogenesis of an epithelium
goid: GO:0002009
definition: Formation and development of an epithelium.
definition_reference: ISBN:0070524300
definition_reference: WB:ems
----------------------------------------------------------------------
12. Egl = EGg Laying defect
Specialization of "post-embryonic defect" and "Morphology defect"
term: oviposition
goid: GO:0018991
definition: The deposition of eggs (either ferilized or not) upon
a surface or into a medium such as water.
definition_reference: WB:ems
----------------------------------------------------------------------
13. Emb = EMBryonic lethal
Specialization of "Lethal" and "embryonic defect"
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
14. Etv = Embryonic Terminal arrest, Variable
Specialization of Defect (was Vab + Var)
term: morphogenesis
goid: GO:0009653
definition: Formation and development of organized structures.
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
15. Fem = FEMinization of XX and XO animals
Specialization of "post-embryonic defect" and "Reproductive defect"
term: masculinization of hermaphroditic germ-line (sensu Nematoda)
goid: GO:0042006
definition: The determination of male sex and sexual phenotype in
the germ-line of hermaphroditic nematodes such as Caenorhabditis
elegans, Caenorhabditis briggsae, and Oscheius sp. CEW1.
definition_reference: WB:ems
and
term: masculinization of hermaphrodite soma (sensu Nematoda)
goid: GO:0042003
definition: Promoting male sex and sexual phenotypes in an
hermaphroditic nematodes's soma.
definition_reference: WB:ems
----------------------------------------------------------------------
16. Fgc = Fewer Germ Cells
Specialization of Ste
term: gametogenesis
goid: GO:0007276
definition: The generation, maintenance, and proliferation of gametes.
definition_reference: WB:ems
----------------------------------------------------------------------
17. Fog = Feminization Of Germline
Specialization of "post-embryonic defect" and "Reproductive defect"
term: masculinization of hermaphroditic germ-line (sensu Nematoda)
goid: GO:0042006
definition: The determination of male sex and sexual phenotype in
the germ-line of hermaphroditic nematodes such as Caenorhabditis
elegans, Caenorhabditis briggsae, and Oscheius sp. CEW1.
definition_reference: WB:ems
----------------------------------------------------------------------
18. Gom = GOnad Migration defect
term: inductive cell migration
goid: GO:0040039
definition: Migration of a cell in a multicellular organism that,
having changed its location, is required to induce normal properties
in one or more cells at its new location. An example of this would
be the distal tip cells of Caenorhabditis elegans.
definition_reference: ISBN:087969307X
definition_reference: ISBN:0879694882
----------------------------------------------------------------------
19. Gon = GONad development abnormal
Specialization of Ste
term: gonad development
goid: GO:0008406
definition: The development of an animal organ that produces
gametes; in some species it also produces hormones.
definition_reference: WB:ems
definition_reference: ISBN:0198506732
----------------------------------------------------------------------
20. Gro = slow GROwth
term: positive regulation of growth rate
goid: GO:0040010
definition: Positively controlling or influencing the rate of growth.
definition_reference: WB:ems
----------------------------------------------------------------------
21. Him = High Incidence of Male progeny
Specialization of "post-embryonic defect" and "Reproductive defect"
term: chromosome segregation
goid: GO:0007059
definition: The separation of chromosomes into daughter cells
during cell division.
definition_reference: SGD:mah
----------------------------------------------------------------------
22. Hya = HYperActive
term: negative regulation of locomotion
goid: GO:0040013
definition: Negatively controlling or influencing the intensity
or frequency of locomotion of an organism.
definition_reference: WB:ems
----------------------------------------------------------------------
23. Led = Late Embryo Defect
Specialization of "Emb" and "embryonic defect"
term: histogenesis and organogenesis
goid: GO:0007397
definition: The generation of organized tissues or of whole organs.
definition_reference: WB:ems
and
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
24. Lin = LINeage abnormal
term: histogenesis and organogenesis
goid: GO:0007397
definition: The generation of organized tissues or of whole organs.
definition_reference: WB:ems
----------------------------------------------------------------------
25. Lon = LONg body
term: negative regulation of body size
goid: GO:0040015
definition: Negatively controlling or influencing the growth of
an organism to reach its usual body size.
definition_reference: WB:ems
----------------------------------------------------------------------
26. Lva = LarVal Arrest
Specialization of "Growth defect" and "Lethal"
term: larval development (sensu Nematoda)
goid: GO:0002119
definition: Development from the newly hatched first-stage larva
to the end of the last larval stage (e.g., fourth-stage in C.
elegans) before molting to adulthood.
definition_reference: WB:ems
and
term: growth
goid: GO:0040007
definition: The increase in size or mass of an entire organism
(as used in GO), as opposed to cell growth (GO:0016049).
definition_reference: FB:ma
----------------------------------------------------------------------
27. Lvl = LarVal Lethal
Specialization of "Lethal" and "post-embryonic defect"
term: larval development (sensu Nematoda)
goid: GO:0002119
definition: Development from the newly hatched first-stage larva
to the end of the last larval stage (e.g., fourth-stage in C.
elegans) before molting to adulthood.
definition_reference: WB:ems
and
term: physiological processes
goid: GO:0007582
definition: Those processes specifically pertinent to the
functioning of integrated living units, i.e., cells, tissues,
organs, and organisms.
definition_reference: WB:ems
definition_reference: ISBN:0198506732
Note: this is the best I can do, since stage-specific survival
isn't currently recognized as a process that can be put in GO.
----------------------------------------------------------------------
28. Mei = defective MEIosis
Specialization of Emb
term: meiosis
goid: GO:0007126
definition: A process by which the nucleus of a diploid cell
divides twice with the formation of four daughter haploid cells,
each containing half the number of chromosomes of the parent
nucleus. Meiosis occurs during the formation of gametes from
diploid cell and at the beginning of haplophase in those
organisms that exhibit alternation of generations. Meiosis
involves two rounds of cell division.
definition_reference: ISBN:0198547684
----------------------------------------------------------------------
29. Mig = cell MIGration abnormal
Specialization of Ste
term: cell migration
goid: GO:0016477
definition: The orderly movement of cells from one site to
another during the development of a multicellular organism.
definition_reference: WB:ems
----------------------------------------------------------------------
30. Mlt = MoLT defect
Specialization of "Growth defect" and "post-embryonic defect"
term: molting
goid: GO:0018988
definition: The periodic shedding of part or all of a cuticle,
which is then replaced by a new cuticle.
definition_reference: WB:ems
----------------------------------------------------------------------
31. Mog = Masculinization Of Germ line
term: feminization of hermaphroditic germ-line (sensu Nematoda)
goid: GO:0040022
definition: The determination of feminine sex and sexual
phenotype in the germ-line of hermaphroditic nematodes such as
Caenorhabditis elegans, Caenorhabditis briggsae, and Oscheius sp.
CEW1.
definition_reference: WB:ems
----------------------------------------------------------------------
32. Mul = MULtiple nuclei in early embryo
Specialization of Emb
term: embryonic cleavage
goid: GO:0040016
definition: The subdivision of activated eggs into blastomeres.
definition_reference: ISBN:0070524300
----------------------------------------------------------------------
33. Muv = MUltiVulva
term: negative regulation of vulval development (sensu Nematoda)
goid: GO:0040027
definition: Negatively controlling or influencing development of
the vulva in nematodes.
definition_reference: WB:ems
----------------------------------------------------------------------
34. Nmo = Nuclear MOrphology alteration in early embryo
Specialization of Emb
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
and
term: nuclear organization and biogenesis
goid: GO:0006997
definition: Synthesis and ordering of the nucleus.
definition_reference: WB:ems
----------------------------------------------------------------------
35. Npo = Nuclear POsition alteration in early embryo
Specialization of Emb
term: nuclear positioning
goid: GO:0040023
definition: The orderly synthesis, assembly, regulation, and
motion of structures that place the nucleus in a specific
position at a defined time within the cell at large.
definition_reference: WB:ems
----------------------------------------------------------------------
36. Ocs = One-Cell arreSt
term: embryonic cleavage
goid: GO:0040016
definition: The subdivision of activated eggs into blastomeres.
definition_reference: ISBN:0070524300
----------------------------------------------------------------------
37. Ooc = OOCyte formation abnormal
Specialization of Ste
term: oocyte construction
goid: GO:0007308
definition: The synthesis, deposition, and organization of a cell
of an animal ovary that can then undergo meiosis and form an
ovum.
definition_reference: WB:ems
definition_reference: ISBN:0198506732
----------------------------------------------------------------------
38. Oth = OTHer phenotype (see Remark)
Specialization of Emb
This needs to be analysed Remark by Remark. As of 1/15/02
there were eight genes with this annotation, to be annotated
individually. Specific instances of Oth phenotypes and their
proposed GO terms for the wild-type alleles are:
......................................................................
JA:C47B2.4:
very active cytoplasm; huge polar bodies
term: cytoplasm organization and biogenesis
goid: GO:0007028
definition: Synthesis and ordering of the cytoplasm and its
components.
definition_reference: WB:ems
......................................................................
JA:F32H2.5:
polar bodies absorbed during first cleavage
term: polar body extrusion after meiotic divisions
goid: GO:0040038
definition: The generation of two small cells, as byproducts destined
to degenerate, as a result of the first and second meiotic divisions
of a primary oocyte during its development to a mature ovum. One polar
body is formed in the first division of meiosis and the other in the
second division; at each division, the cytoplasm divides unequally, so
that the polar body is of much smaller size than the developing oocyte.
At the second division in which a polar body is formed, the polar body
and the developing oocyte each contain a haploid set of chromosomes.
definition_reference: ISBN:0198506732
definition_reference: WB:ems
......................................................................
JA:F32H2.6:
polar bodies absorbed during first cleavage
term: polar body extrusion after meiotic divisions
goid: GO:0040038
definition: The generation of two small cells, as byproducts destined
to degenerate, as a result of the first and second meiotic divisions
of a primary oocyte during its development to a mature ovum. One polar
body is formed in the first division of meiosis and the other in the
second division; at each division, the cytoplasm divides unequally, so
that the polar body is of much smaller size than the developing oocyte.
At the second division in which a polar body is formed, the polar body
and the developing oocyte each contain a haploid set of chromosomes.
definition_reference: ISBN:0198506732
definition_reference: WB:ems
......................................................................
JA:F57B10.10:
multiple female pronuclei
term: female meiosis
goid: GO:0007143
definition: Meiosis (GO:0007126) in the female germline.
definition_reference: WB:ems
......................................................................
JA:K07A1.12:
abnormal nuclear morphology
term: nuclear organization and biogenesis
goid: GO:0006997
definition: Synthesis and ordering of the nucleus.
definition_reference: WB:ems
......................................................................
JA:M01A10.3:
multiple female pronuclei
term: female meiosis
goid: GO:0007143
definition: Meiosis (GO:0007126) in the female germline.
definition_reference: WB:ems
......................................................................
JA:R09B3.4:
no pronuclear migration
term: pronuclear fusion
goid: GO:0007344
definition: The merging of two pronuclei in a fertilized egg to
fuse and produce a single zygotic genome.
definition_reference: WB:ems
definition_reference: ISBN:087969307X
......................................................................
JA:Y71F9A_279.b:
multiple female pronuclei
term: female meiosis
goid: GO:0007143
definition: Meiosis (GO:0007126) in the female germline.
definition_reference: WB:ems
......................................................................
----------------------------------------------------------------------
39. Pna = ProNuclear envelope Alteration
Specialization of Emb (was Pne + Pna)
term: pronuclear envelope synthesis
goid: GO:0018985
definition: Synthesis and ordering of the envelope of pronuclei.
definition_reference: WB:ems
----------------------------------------------------------------------
40. Pnm = ProNuclear Migration alteration in early embryo
Specialization of Emb (was Prm)
term: pronuclear fusion
goid: GO:0007344
definition: The merging of two pronuclei in a fertilized egg to
fuse and produce a single zygotic genome.
definition_reference: WB:ems
definition_reference: ISBN:087969307X
----------------------------------------------------------------------
41. Prl = PaRaLyzed
Has synonym, "prz".
term: locomotion
goid: GO:0040011
definition: Performing basic movements of any kind.
definition_reference: WB:ems
----------------------------------------------------------------------
42. Prm = PRonuclear Migration alteration in early embryo
[currently a deprecated term]
Specialization of Emb (is now officially Pnm)
term: pronuclear fusion
goid: GO:0007344
definition: The merging of two pronuclei in a fertilized egg to
fuse and produce a single zygotic genome.
definition_reference: WB:ems
definition_reference: ISBN:087969307X
----------------------------------------------------------------------
43. Pvl = Protruding VulVa
Specialization of "Morphology defect" and "post-embryonic defect"
term: hermaphrodite genital morphogenesis
goid: GO:0040035
definition: Formation and development of organized structures in
hermaphrodite genitals.
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
45. Rol = ROLler
Specialization of "Movement defect" and "post-embryonic defect"
term: cuticle synthesis
goid: GO:0007592
definition: Synthesis and deposition of a noncellular, hardened,
or membranous secretion from an epithelial sheet.
definition_reference: WB:ems
----------------------------------------------------------------------
46. Rup = RUPtured, i.e., exploded
Specialization of "Morphology defect" and "post-embyronic defect"
term: morphogenesis of an epithelium
goid: GO:0002009
definition: [Formation and development of an epithelium.]
definition_reference: [ISBN:0070524300]
definition_reference: [WB:ems]
----------------------------------------------------------------------
47. Sck = SiCK
Specialization of "Growth defect" and "post-embryonic defect"
term: physiological processes
goid: GO:0007582
definition: Those processes specifically pertinent to the
functioning of integrated living units, i.e., cells, tissues,
organs, and organisms.
definition_reference: WB:ems
definition_reference: ISBN:0198506732
----------------------------------------------------------------------
48. Sle = SLow Embryonic development
Specialization of "embryonic defect"
term: positive regulation of embryonic development rate
goid: GO:0040019
definition: Positively controlling or influencing the rate of
embryonic development.
definition_reference: WB:ems
----------------------------------------------------------------------
49. Slu = SLUggish
Specialization of "Movement defect"
term: positive regulation of locomotion
goid: GO:0040017
definition: Positively controlling or influencing the intensity
or frequency of locomotion of an organism.
definition_reference: WB:ems
----------------------------------------------------------------------
50. Sma = SMAll
Specialization of "Growth defect", "Morphology defect", and
"post-embryonic defect"
term: positive regulation of body size
goid: GO:0040018
definition: Positively controlling or influencing the growth of
an organism to reach its usual body size.
definition_reference: WB:ems
----------------------------------------------------------------------
51. Spd = SPinDle, abnormal embryonic
Specialization of Spo (was Sas + Spd)
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
and
term: spindle assembly
goid: GO:0007051
definition: The formation and maintenance of the spindle in
mitosis or meiosis.
definition_reference: SGD:mah
----------------------------------------------------------------------
52. Spi = SPIndle position and orientation abnormal [to become
official term, replacing "Spo"]
Specialization of Emb (also known as Spo)
term: mitotic spindle positioning and orientation
goid: GO:0040001
definition: The intracellular positioning and orientation of the
mitotic spindle.
definition_reference: WB:ems
and
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
53. Spn = abnormal SPiNdle orientation
Specialization of Spo
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
and
term: mitotic spindle orientation
goid: GO:0000132
definition: The intracellular orientation of the mitotic spindle.
definition_reference: WB:ems
----------------------------------------------------------------------
54. Spo = abnormal embryonic Spindle Position and Orientation [to
soon be deprecated]
Specialization of Emb (will be renamed Spi)
term: mitotic spindle positioning and orientation
goid: GO:0040001
definition: The intracellular positioning and orientation of the
mitotic spindle.
definition_reference: WB:ems
and
term: embryogenesis and morphogenesis
goid: GO:0007345
definition: Formation and development of an embryo and its
organized structures.
definition_reference: ISBN:0070524300
definition_reference: ISBN:0140512888
definition_reference: WB:ems
----------------------------------------------------------------------
55. Ste = STErile
Specialization of "post-embryonic defect" and "Reproductive defect"
term: reproduction
goid: GO:0000003
definition: The production by an organism of new individuals
that contain some portion of their genetic material inherited
from that organism.
definition_reference: GO:curators
definition_reference: ISBN:0198506732
----------------------------------------------------------------------
56. Stp = STerile Progeny
Specialization of "post-embryonic defect" and "Reproductive defect"
term: gametogenesis
goid: GO:0007276
definition: The generation, maintenance, and proliferation of
gametes.
definition_reference: WB:ems
----------------------------------------------------------------------
57. Tum = TUMorous germ line
Specialization of Ste
term: gametogenesis
goid: GO:0007276
definition: The generation, maintenance, and proliferation of
gametes.
definition_reference: WB:ems
and
term: control of meiosis
goid: GO:0040020
definition: The activation and inhibition of meiosis, the process
by which the nucleus of a diploid cell divides twice forming four
haploid cells, one or more of which usually function as gametes.
definition_reference: WB:ems
definition_reference: FB:ma
----------------------------------------------------------------------
58. Unc = UNCoordinated
Specialization of "Movement defect" and "post-embryonic defect"
term: locomotory behavior
goid: GO:0007626
definition: The abilities associated with normal movement,
including both general motion and specifically coordinated
patterns of activity.
definition_reference: WB:ems
----------------------------------------------------------------------
59. Var = VARiable terminal arrest
Specialization of Emb
term: morphogenesis
goid: GO:0009653
definition: Formation and development of organized structures.
definition_reference: ISBN:0140512888; WB:ems
----------------------------------------------------------------------
60. Vul = VULvaless
term: positive regulation of vulval development (sensu Nematoda)
goid: GO:0040026
definition: Positively controlling or influencing development of
the vulva in nematodes.
definition_reference: WB:ems
----------------------------------------------------------------------