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|Sensory neuron (Mechanosensory)||V5Lpaapa
|Lateral in posterior body||
Born postembryonically (see V lineage). PVDL/R have extensive branching pattern in adult animals (Hobert O. & Treinin M., pers. comm). In larval stages 3 major processes are discerned; one anteriorly directed, one posteriorly directed and one ventrally directed. These processes show short extensions and branches along their length. As the animal ages, this branching pattern is elaborated extensively and covers most of the body.
Functions: Putative stretch-sensing mechanosensor. PVD mediates a response to harsh mechanical stimuli (Way J. C. and Chalfie M., 1989). Animals in which PVD neurons are laser-ablated fail to respond to harsh touch to the central region of the body but can can respond to harsh head and tail tap. PVD is possibly not involved in the circuit that mediates suppression of pumping in response to a touch stimulus in adults (Keane J. and Avery L., 2003)
Receptor expression: Express MEC-10 (degenerin) which comprises part of a mechanosensory transduction channel (Huang M. and Chalfie M. , 1994), MEC-9 which is suggested to provide an extracellular attachment point for the mechanosensory channels in touch cells (Du H. et al, 1996) and MEC-6 which is part of the degenerin/epithelial Na+ channel complex (Chelur D. S. et al, 2002). Express TRPV channel protein OSM-9 (Colbert H.A. et al 1997). Express a splice variant of the tyramine receptor SER-2 (Tsalik E. L. et al, 2003, Rex E. and Komuniecki R.W., 2002). Express alpha subunits of a nicotinic acetylcholine receptor, DEG-3 and DES-2 (Treinin M. and Chalfie M. 1995, Treinin M. et al 1998). Express glutamate receptor subunit, GLR-4 (Brockie P.J. et al 2001).