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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

FLPL
FLPR

Sensory neuron (Mechanosensory)

AB plapaaapad
AB prapaaapad
Head

Glutamate.

Express VGluT, EAT-4 (Lee R.Y.N. et al 1999)

None
DESCRIPTION

Have ciliated endings in head, not part of a sensillum. The endings are not open to outside. Wrap around a branch of the lateral ILso cell just below the region where the socket cell surrounds the IL neurons.

Functions: Nose touch avoidance. Nose-on collision with an object such as an eyelash initiates backward movement of C. elegans. Three classes of mechanosensory neurons (ASH, FLP, and OLQ) act in parallel to mediate this response. Each sensory neuron class accounts for a fraction of the normal response, as follows: ASH, 45%; FLP, 29%; and OLQ, 5%. The remaining responses (~10%) are mediated by the ALM and AVM neurons, which sense anterior body touch (Kaplan J. and Driscoll M., 1997).

Receptor expression: Express mammalian capsaicin receptor-like channel protein OSM-9 (Colbert H.A. et al 1997). Express alpha subunits of a nicotinic acetylcholine receptor, DEG-3 and DES-2 (Treinin M. and Chalfie M. 1995, Treinin M. et al 1998). Express glutamate receptor subunit, GLR-4 (Brockie P. J. et al 2001). Express MEC-10 (degenerin) which comprise part of a mechanosensory transduction channel (Huang M. X. and Chalfie M., 1994). Express DEL-1, a DEG/ENaC family member which may be a subunit of a mechanically gated ion channel that contributes to nematode proprioception (Tavernarakis N. et al, 1997). Express UNC-8, a DEG/ENaC family member homologous to subunits of a candidate mechanically gated ion channel (Tavernarakis N. et al, 1997).