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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

AVG

Interneuron

AB prpapppap Retrovesicular ganglion of head

Not known

None
DESCRIPTION

Ventral cord interneuron, few synapses, sends process into tailspike.

Function: Anterior guidepost neuron. AVG pioneers the right tract of the ventral nerve cord. It expresses UNC-6 at 3-fold embryo stage to provide a continuous UNC-6 (netrin)-labeled pathway restricted to the right tract of the nerve cord. The unilateral UNC-6 cue from AVG guides various paired axons growing from the nerve ring and lumbar ganglia to make rightward decussations as they enter the ventral nerve cord. UNC-6 also promotes bundling of axons within the cord itself. If the parent of AVG is ablated in wild-type embryos, interneurons and ventral cord motor neurons form several small fascicles rather than one tight bundle of right side tract and occasionally the right side axons shift to the left side (Wadsworth W.G et al 1996, Wadsworth W. G. and Hedgecock E. M., 1986, Durbin R., 1987, Antebi A. et al, 1997).

Receptor expression: Expresses glutamate receptor subunits, GLR-1, GLR-2, NMR-1 and NMR-2 (Maricq A. V. et al 1995)(Brockie P.J. et al 2001). Expresses alpha subunit of a nicotinic acetylcholine receptor, DEG-3 (Treinin M. and Chalfie M. 1995)