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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

ALML
ALMR

Sensory neuron (Mechanosensory) AB arppaappa
AB arpppappa
Lateral in mid-body

Glutamate

Expresses VGluT, EAT-4 (Lee R.Y.N. et al 1999)

None
DESCRIPTION

Anterior lateral microtubule cells, touch receptor neurons.

Functions: Along with AVM and PLM, sense touch to the body and provide input to the command (inter)neurons (PVC, AVB, AVD, AVA) via both synaptic connections and gap junctions (Chalfie et al. 1985). The touch cells form gap junctions with agonist interneurons and chemical synapses with the antagonist interneurons. Hence, the anterior touch cells ALML/R and AVM form gap junctions with the backward movement interneuron AVD, but they provide synaptic input to the forward interneurons (AVB and PVC) (Kaplan J. and Driscoll M., 1997).

See body touch circuit here.

Receptor expression: Express MEC-2 (stomatin-like), MEC-4 (degenerin), MEC-10 (degenerin) which comprise part of a mechanosensory transduction channel (Huang M.X. et al 1995; Lai C.C. et al 1996; Huang M. and Chalfie, 1994). Express MEC-9 which is suggested to provide an extracellular attachment point for the mechanosensory channels in touch cells (Du H. et al, 1996) and MEC-6 which is part of the degenerin/epithelial Na+ channel complex (Chelur D. S. et al, 2002). Express glutamate receptor subunit, GLR-8 (Brockie P.J. et al 2001). Express alpha subunits of a nicotinic acetylcholine receptor, DEG-3 and DES-2 (Treinin M. and Chalfie M. 1995, Treinin M. et al 1998). Express the dopamine receptor DOP-1 (Tsalik E. L. et al, 2003, Sanyal S. et al, 2004).





The posterior process coming out of ALM cell body (red arrows, below) is infrequently seen and can be at random legths: