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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

AIYL
AIYR

Interneuron AB plpapaaap
AB prpapaaap
Ventral ganglion of head

Acetylcholine (Altun-Gultekin et al 2001).

Express the FMRFamide-related neuropeptide (FaRP), FLP-18 (Rogers C. et al, 2003).

None
DESCRIPTION

Amphid Interneurons.

Functions: Involved in thermosensation. Laser ablation of the AIY pair makes the animals cryophilic. See model below. (Mori I. and Ohshima Y. 1995).

Receptor expression: Express two separate splice variants of the tyramine receptor SER-2 (Altun-Gultekin et al., 2001, Tsalik E. L. et al, 2003). Express G protein-coupled serpentine receptor, SRA-11 (Troemel E. et al 1995). Also predicted to express 24 G protein-coupled 7TM receptors (20 neuropeptide receptors + 2 biogenic amine receptors, including SER-2 + 2 metabotropic ACh/GABA/Glu repetors) and 6 ligand-gated ion channels (Wenick A. S. and Hobert O. 2004)








IDENTIFICATION:

The three neurons, AIM, AIY and AVK resemble pearls-on-a-string, located posterior and slightly more superficial to the excretory cell nucleus on the right and left sides of the head.
The nucleus of the excretory cell is the biggest one on the ventral side, below the terminal bulb of the pharynx and looks like an egg with a sunny-side-up appearance. The three neuronal nuclei can easily be located immediately posterior to the excretory cell nucleus, the most anterior one being AIM, the middle, AIY, and the most posterior one, AVK. On the right side, sometimes RIS nucleus accompanies these three nuclei.
Cell and axon structures of AIY and AIM are very similar; care must be taken to differentiate between the two when identifying these two cells with fluorescent markers.