Compiled by Lindy Holden-Dye and Robert J. Walker, Neuroscience Research Group, University of Southampton UK. Comments to lmhd@soton.ac.uk.
NEUROTRANSMITTER Pharmacological actions of ‘classical’ neurotransmitters on nematode muscle
C.elegans pharynx A. suum body wall muscle A.suum vagina vera muscle
Acetylcholine ( ACh)

direct-excitatory

(Bessou C et al. 1998)

direct-excitatory

(Baldwin, E. & Moyle, V. 1949 British Journal of Pharmacology 4, 145-152)

(Pennington, A. & Martin, R.J. 1990)

(Colquhoun et al., 1991)

excitatory

(Fellowes et al., 2000)

 

Gammaaminobutyric acid (GABA)

weak inhibitory

(Holden-Dye, unpublished observations)

direct-inhibitory

(Del Castillo J. et al.,1964 Nature 203, 530-531)

(Martin, R.J. 1985)

(Holden-Dye, L. et al. 1989)

inhibitory

(Fellowes et al., 2000)

Glutamate

direct- inhibitory

(Avery L.1993)

(Pemberton D. et al., 2001)

indirect-inhibitory

(Davis, R.E. 1998)

inhibitory

(Fellowes et al., 2000)

Serotonin

direct and indirect- excitatory

(Rogers C.M., et al., 2001)

indirect- inhibitory

(Trim J.E. et al., 2001)

 

no consistent effect

(Fellowes et al., 2000)

 

Dopamine

indirect?-excitatory

(Holden-Dye, unpublished observations)

indirect- inhibitory

(Chen X.H. et al., 1997 Journal of Physiology-London 504P, 24-25)

N.D.
Octopamine

indirect-inhibitory

(Rogers C.M., et al., 2001)

indirect-inhibitory

(Holden-Dye, unpublished observations)

N.D.
Nitric oxide N.D.

inhibitory

(Bascal Z.A. et al., 2001)

N.D.


This information is derived from experiments using in vitro muscle preparations to measure responses. N.D.- not determined. ‘direct’ or ‘indirect’ indicates whether the effect is due to a direct action on the muscle, or indirect through a neural circuit.

WA EDITORS' NOTE:

GABA is excitatory for enteric muscle in C. elegans (Reiner D.J. and Thomas J.H. 1995). Suggested excitatory GABA receptors include EXP-1 and Y46G5A.26 gene product (Beg A.A. and Jorgensen E., 2001). It has inhibitory action for body wall muscle which is carried through the inhibitory GABA receptor UNC-49 (Bamber B. A. et al, 1999)

Serotonin is excitatory for hermaphrodite reproductive muscle in C. elegans (Horvitz H.R., et al 1982)

Octopamine is inhibitory for hermaphrodite reproductive muscle in C. elegans (Horvitz H.R., et al 1982)