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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

I2L
I2R

Pharyngeal Interneuron

AB.alpappaapa
AB.arapapaapa

Pharynx anterior bulb

Express neuropeptide-like proteins NLP-3 and NLP-8 (Nathoo A. et al 2001).

None
DESCRIPTION

Pharyngeal interneurons. At the most anterior end of the subventral nerve cords, I2s have proprioceptive-like free subcuticular endings slightly anterior to those of I1s. They are also coupled by gap junctions to M1 neurons and attach to pm1 muscle at the anterior end. Their posterior processes terminate anterior to the cell bodies of M3 neurons (Albertson D. J. and Thomson J. N., 1976).

Functions: Unknown or redundant (Avery L, and Thomas J. H., 1997).

Receptor expression: Express glutamate receptor subunits, GLR-7 , GLR-8 (Brockie P.J. et al 2001). Suggested to express G-protein coupled muscarinic acetylcholine receptor ACM-2 (F47D12.2). acm-2 mutants display an increased pharyngeal pumping rate and an increased sensitivity to nicotine (Steger K and Avery L., 2001).