AVE
The Mind of 
	a Worm

Members: AVEL, AVER.

AVE is a pair of interneurons with cell bodies situated in the lateral ganglion close to the ring neuropile. Processes from the cell bodies enter the ring laterally and run anteriorly through the neuropile until they are near the anterior surface. They then turn dorsally and start running round the ring in close association with the processes of AIB. When the processes of AVE reach the dorsal mid-line they turn and run anteriorly for a short distance until the anterior surface is reached, where they turn again and carry on round the ring in close association with the processes of RIB, until they leave the ring ventrally and enter the ventral cord. They run near the centre of the nerve cord (figure 18) and eventually end before the vulva is reached (j). The processes of AVE are exclusively postsynaptic in the nerve ring and are lightly staining in this region. They receive many synapses, particularly from the mechanosensory system. The main synaptic input is from OLL (*a), URY(*b), CEP (*d), URX (*b), DVA (*a), RIB (*h), RIS (*a), BAG (*c) and AUA (*b); there are also a few synapses from FLP (*b), ALA (*a), AVK (*a), AIZ, RIG, PVC (*a) and RMG. There are gap junctions to RIM (*h), RME (g) and RMD (h) in the ring. AVE is predominantly presynaptic in the ventral cord and has the same postsynaptic partners as AVD. It makes many synapses onto AVA (a) and also several onto SAB (b, c), VAn (c, e), DAn (d) and ASn (f), usually in various dyadic combinations. There are some striking synaptic complexes in the vicinity of the SAB cell bodies, where both AVEL and AVER have presynaptic specializations in the same region with processes of SAB, VA1 and DA1 sandwiched in between (c). There is some synaptic input from AVJ (*d) and AVB (*d) in the ventral cord. Magnifications: (a, g, h) x 25500, (b-f) x 17000.


AVE ventral cord synapses
partners gap junctions synapses from synapses to and corecipients
AVA - 3m 8, 6DA1, 5DA2, 4SABV, 4AS1, 4AVA, 2DA3, 2AS2, 2DB3, 2VA2, PVC, VA3, DA4, AVD, 1VA4
SABV - - 4SABD, 4AVA, 4DA1, 3VA1, 2SABV
DA1 - - 6AVA,4SABV,2SABD
SABD - - 4SABV, 2VA1, 2DA1
VA1 - - 3SABV, 2SABD, VA3
VA3 - - 3, AVA, VD3, VA1
DA2 - - 1,5AVA
AS1 - - 1,4AVA
DA3 - - 2, 2AVA
DB3 - - 2AVA
AS2 - - 2AVA
VA2 - - 2AVA
PVC - 1m AVA
DVB - - VD2
VD2 - - DVB
VD3 - - VA3
DA4 - - AVA
AVD - - AVA
AS3 - - 1
VA6 - - 1
VA4 - - AVA
AVJ - 2+2m -
AVB - 1+1m -
AVG - 2m -
AVL - 1m -


Web adaptation, Thomas Boulin, for Wormatlas, 2001, 2002