LUAL, LUAR

Type: Interneuron
In MoW: LUA
Male Wiring Project: LUAL, LUAR
In Wormbase: LUAL, LUAR
Lineage: AB plpppaapap, AB prpppaapap
Location: Left and right lumbar ganglia
Description: Interneuron
Neurotransmitter/ Neuropeptide:
- Glutamate
- NLP-13; neuropeptide-like protein
- PDF-1; pigment dispensing factor homolog
(Pereira et al., 2015; Barrios et al, 2012; Nathoo et al., 2001)
Innexin expression:
- INX-7
- INX-11
- INX-13
(Altun et al., 2009)
Receptor expression:
- GLR-5; glutamate receptor subunit
- SER-2; tyramine receptor (a splice variant)
(Tsalik et al., 2003; Brockie et al., 2001)
Function:
- Suggested to be a "connector cell" between the PLM touch receptors, with which they make gap junctions along the lumbar commissures, and AVA/D interneurons, with which they make chemical synapses in the ventral cord (Chalfie et al., 1985). However, laser ablation does not lead to any abnormalities of movement or touch sensitivity (Chalfie et al., 1985) and no role in tap-withdrawal reflex has been found (Wicks and Rankin, 1995)

 
 

 
 

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LUAL (AB plpppaapap) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of LUAL (since last LUAL ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB plpppaapa); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).
 
 

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LUAR (AB prpppaapap) development in the embryo. Dorsal view. Bottom is left side of the embryo. Spheres indicate individual nuclei. Black sphere: ancestors of LUAR (since last LUAR ancestor has not yet gone through its final division, the black sphere seen at the end of this movie is still AB prpppaapa); dark grey spheres: apoptotic cells; other cells follow the WA color code (after they acquire specific cell or tissue identities). 0 min is fertilization. Click on the movie for higher resolution rendition (by A. Santella & Z. Bao).

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