Type: Interneuron
In MoW: PVT
Male Wiring Project: PVT
In Wormbase: PVT
Lineage: AB plpappppa|
Location: Pre-anal ganglion
Description: Interneuron, projects along ventral cord to ring. Hermaphrodites and males exhibit some differences in PVT connectivity.
Neurotransmitter:
Function: Midline neuroblast, secretes UNC-6, serves as a guidepost neuron to guide growing axons from the lumbar ganglia in the posteriormost region of the ventral cord. When PVT is ablated embryonically, these axons follow multiple routes to enter the ventral cord instead of making tight bundles (Antebi et al., 1997; Ren et al., 1999). Postembryonically, PVT functions to keep the ventral cord fascicles intact. Early larval ablation of PVT induces axons of AVKL/R, PVQL/R, HSNL/R and RMEV to aberrantly cross the ventral midline (Aurelio et al., 2002).
Receptor Expression: Expresses a splice variant of the tyramine receptor SER-2 (variable expression) (Tsalik et al., 2003). Expresses the serotonin receptors, SER-1 (Dernovici et al, 2007; Carnell et al, 2005) and SER-4 (variable expression) (Tsalik et al., 2003).