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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

PVM

Sensory neuron (mechanosensory)
QL paa
Lateral. Left side of the posterior half of the body.
Unknown
None

DESCRIPTION

Posterior ventral microtubule cell, generated postembryonically (AVM and PVM are generated at about 9 hours after hatching at 20°C, about 19 hours after egg deposition.). In the L1 stage, PVM extends a process that first grows ventrally along a commissure on the left side of the posterior body and then turns anteriorly when it reaches the ventral nerve cord (VNC). Within VNC the PVM process runs anteriorly on the ventral side adjacent to the cuticle. PVM is an unbranched unipolar neuron.

Functions: PVM is ultrastructurally very similar to the other touch cells, and its differentiation is controlled by the same genetic pathway that controls differentiation of the other five touch receptor neurons. However, PVM does not mediate a locomotory response to gentle touch (Chalfie M and Sulston J., 1981) and does not appear to have a critical role in touch sensitivity (for discussion see Kaplan J. and Driscoll M., 1997). It is postulated to be a stretch receptor.

Receptor expression: Expresses G protein-linked acetylcholine receptor, GAR-1(Lee Y. S. et al, 2000). Expresses MEC-2 (stomatin-like), MEC-4 (degenerin), MEC-10 (degenerin) which comprise part of a mechanosensory transduction channel (Huang M.X. et al 1995; Lai C.C. et al 1996). Expresses MEC-9 which is suggested to provide an extracellular attachment point for the mechanosensory channels in touch cells (Du H. et al, 1996) and MEC-6 which is part of the degenerin/epithelial Na⁺ channel complex (Chelur D.S. et al, 2002). Expresses UNC-8, a DEG/ENaC family member homologous to subunits of a candidate mechanically gated ion channel (Tavernarakis N. et al, 1997).

CELL	TYPE	LINEAGE	LOCATION	NEUROTRANSMITTER	ASSOCIATED GLIA
PVM	Sensory neuron (mechanosensory)	QL paa	Lateral. Left side of the posterior half of the body.	Unknown	None
DESCRIPTION
Posterior ventral microtubule cell, generated postembryonically (AVM and PVM are generated at about 9 hours after hatching at 20°C, about 19 hours after egg deposition.). In the L1 stage, PVM extends a process that first grows ventrally along a commissure on the left side of the posterior body and then turns anteriorly when it reaches the ventral nerve cord (VNC). Within VNC the PVM process runs anteriorly on the ventral side adjacent to the cuticle. PVM is an unbranched unipolar neuron. Functions: PVM is ultrastructurally very similar to the other touch cells, and its differentiation is controlled by the same genetic pathway that controls differentiation of the other five touch receptor neurons. However, PVM does not mediate a locomotory response to gentle touch (Chalfie M and Sulston J., 1981) and does not appear to have a critical role in touch sensitivity (for discussion see Kaplan J. and Driscoll M., 1997). It is postulated to be a stretch receptor. Receptor expression: Expresses G protein-linked acetylcholine receptor, GAR-1(Lee Y. S. et al, 2000). Expresses MEC-2 (stomatin-like), MEC-4 (degenerin), MEC-10 (degenerin) which comprise part of a mechanosensory transduction channel (Huang M.X. et al 1995; Lai C.C. et al 1996). Expresses MEC-9 which is suggested to provide an extracellular attachment point for the mechanosensory channels in touch cells (Du H. et al, 1996) and MEC-6 which is part of the degenerin/epithelial Na⁺ channel complex (Chelur D.S. et al, 2002). Expresses UNC-8, a DEG/ENaC family member homologous to subunits of a candidate mechanically gated ion channel (Tavernarakis N. et al, 1997).