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CELL TYPE LINEAGE LOCATION NEUROTRANSMITTER ASSOCIATED GLIA

AVG

Interneuron
AB prpapppap Retrovesicular ganglion of head
Not known
None

DESCRIPTION

Ventral cord interneuron, few synapses, sends process into tailspike.

Function: Anterior guidepost neuron. AVG pioneers the right tract of the ventral nerve cord. It expresses UNC-6 at 3-fold embryo stage to provide a continuous UNC-6 (netrin)-labeled pathway restricted to the right tract of the nerve cord. The unilateral UNC-6 cue from AVG guides various paired axons growing from the nerve ring and lumbar ganglia to make rightward decussations as they enter the ventral nerve cord. UNC-6 also promotes bundling of axons within the cord itself. If the parent of AVG is ablated in wild-type embryos, interneurons and ventral cord motor neurons form several small fascicles rather than one tight bundle of right side tract and occasionally the right side axons shift to the left side (Wadsworth W.G et al 1996, Wadsworth W. G. and Hedgecock E. M., 1986, Durbin R., 1987, Antebi A. et al, 1997).

Receptor expression: Expresses glutamate receptor subunits, GLR-1, GLR-2, NMR-1 and NMR-2 (Maricq A. V. et al 1995)(Brockie P.J. et al 2001). Expresses alpha subunit of a nicotinic acetylcholine receptor, DEG-3 (Treinin M. and Chalfie M. 1995)

CELL	TYPE	LINEAGE	LOCATION	NEUROTRANSMITTER	ASSOCIATED GLIA
AVG	Interneuron	AB prpapppap	Retrovesicular ganglion of head	Not known	None
DESCRIPTION
Ventral cord interneuron, few synapses, sends process into tailspike. Function: Anterior guidepost neuron. AVG pioneers the right tract of the ventral nerve cord. It expresses UNC-6 at 3-fold embryo stage to provide a continuous UNC-6 (netrin)-labeled pathway restricted to the right tract of the nerve cord. The unilateral UNC-6 cue from AVG guides various paired axons growing from the nerve ring and lumbar ganglia to make rightward decussations as they enter the ventral nerve cord. UNC-6 also promotes bundling of axons within the cord itself. If the parent of AVG is ablated in wild-type embryos, interneurons and ventral cord motor neurons form several small fascicles rather than one tight bundle of right side tract and occasionally the right side axons shift to the left side (Wadsworth W.G et al 1996, Wadsworth W. G. and Hedgecock E. M., 1986, Durbin R., 1987, Antebi A. et al, 1997). Receptor expression: Expresses glutamate receptor subunits, GLR-1, GLR-2, NMR-1 and NMR-2 (Maricq A. V. et al 1995)(Brockie P.J. et al 2001). Expresses alpha subunit of a nicotinic acetylcholine receptor, DEG-3 (Treinin M. and Chalfie M. 1995)